Volume 30, Number 1 (1-2016)                   Med J Islam Repub Iran 2016 | Back to browse issues page


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Homami A, Ghazi F. MicroRNAs as biomarkers associated with bladder cancer. Med J Islam Repub Iran. 2016; 30 (1) :1282-1289
URL: http://mjiri.iums.ac.ir/article-1-4213-en.html

PhD, Associate Professor Department of Medical Genetics and Molecular Biology, Iran University of Medical Sciences, Tehran, Iran. , ghazi.f@iums.ac.ir
Abstract:   (1411 Views)

Bladder cancer is the fifth most common cancer with significant morbidity and mortality. Recently, numerous studies demonstrated that microRNAs are emerging as diagnostic biomarkers for bladder cancer. Specific miRNA profiles have been identified for several samples from patients with bladder cancer. MicroRNAs are noncoding RNA molecules of approximately 23 nucleotides that play important roles in multiple steps during the progression of bladder cancer. Here, we review the expression profiles of miRNAs and their biological functions, regulation, and clinical implications in bladder cancer. Either downregulation or upregulation of miRNAs

occurs in bladder cancer through epigenetic changes or defects of the biogenesis apparatus. Deregulation of miRNAs is involved in cell cycle arrest, apoptosis, proliferation, metastasis, drug resistance, and other functions in bladder cancer. A number of miRNAs, have been associated with tumor type, stage, or patient survival, and miRNAs might be developed as diagnostic or prognostic markers. A better understanding of the roles of miRNAs in bladder cancer will shed light on the molecular mechanisms of bladder cancer.

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Type of Study: Original Research | Subject: Medical Genetics

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