Volume 10, Issue 3 (11-1996)                   Med J Islam Repub Iran 1996 | Back to browse issues page

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From the Department of Cardiology, Balcali Hospital, Cukurova University, Adana, Turkey.
Abstract:   (2776 Views)
The purpose of this investigation was to assess the effect of captopril on both systemic (P.a) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44±6.8 years) with HAPH and mild to moderate systemic arterial hypertension were included in the study. All patients underwent right heart catheterization with measurements of systolic PPA (PPA,syst) , mean PPA, (P¯PA) and diastolic PPA (PPA,diast)• After 4 weeks placebo phase patients with a PPA, sst> 25 mmHg, P¯PA > 15 mm Hg and systemic diastolic blood pressure (Pa,diast) >100 mmHg were given captopril (50-75 mg at 8 am) for a period of 12 weeks. The statistical evaluation of the results was made using Student's t-test. It was found that captopril significantly decreases PPA and Pa.
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Type of Study: Original Research | Subject: Cardiovascular Surgery