Volume 2, Issue 1 (5-1988)                   Med J Islam Repub Iran 1988 | Back to browse issues page

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From the Department of Medicine, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
Abstract:   (2877 Views)
During a period of 4 years (1983-1986), we have seen 18 patients with esophageal ulcer following the intake of doxycycline capsules at the University Hospitals of Shiraz Medical School. During the same period only one other patient with a drug-induced esophageal ulcer was seen and this was found to be due to a mefenemic acid capsule. Diagnosis was made by esophagoscopy and after two weeks, follow-up endoscopies revealed complete healing of the ulcers. After one year, the follow-up observations of ten patients revealed no stricture or obstruction. We conclude that doxycycline capsule is the single most common cause of drug-induced esophageal ulcers and although a self-limited complication, in already ill patients, it produces significant morbidity which could be prevented by simple measures.
Full-Text [PDF 289 kb]   (2398 Downloads)    
Type of Study: Original Research | Subject: Internal Medicine