Volume 8, Issue 2 (8-1994)                   Med J Islam Repub Iran 1994 | Back to browse issues page

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AZARM T. SALVAGE CHEMO THERAPY WITH CYCLOPHOSPHAMIDE, DOXORUBICIN, AND CISPLATIN (CAP) IN ADVANCED BREAST CANCER. Med J Islam Repub Iran 1994; 8 (2) :75-80
URL: http://mjiri.iums.ac.ir/article-1-1382-en.html
SALVAGE CHEMO THERAPY WITH CYCLOPHOSPHAMIDE, DOXORUBICIN, AND CISPLATIN (CAP) IN ADVANCED BREAST CANCER
TALEB AZARM
From the Division of Hematology /Medical Oncology. Seyyed-al Shohada Hospital, Isfahan University of Medical Sciences. Isfahan, Islamic Republic of Iran.
Abstract:   (5534 Views)
Twenty-one patients with advanced breast cancer (7 premenopausal and 14 postmenopausal women) were treated with a combination of cyclophosphamide, doxorubicin, and cisplatin (CAP). The median age of the patients was 43 years (range 36-61). This therapy was repeated every 3 weeks. Nine patients (group 1) received CAP as primary therapy for metastatic breast cancer, and twelve patients (group 2) received CAP as a second-line therapeutic agent. Of the 12 (57%) patients who responded, six (29%) had complete response (CR). The median disease-free survival (DFS) was 8 months. The response rate was highest for metastases in the pleura (83%) and lymph nodes (81 %), followed by skin (64%), liver and breast (55%). The overall response rate was higher in previously untreated patients than in those previously treated (89% versus 33%, p
Keywords: Breast cancer, combination chemotherapy, CAP regimen.
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Type of Study: Original Research | Subject: Oncology
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