Volume 7, Number 3 (11-1993)                   Med J Islam Repub Iran 1993 | Back to browse issues page


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SADEGHI-LOUYEH A, SIMONIAN Y. POSSIBLE INVOLVEMENT OF GABAA RECEPTOR SITES IN CATALEPSY. Med J Islam Repub Iran. 1993; 7 (3) :179-182
URL: http://mjiri.iums.ac.ir/article-1-1428-en.html

From the Department of Physiology Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Abstract:   (1673 Views)
The present work was performed to show the possible interaction of GAB A, and GABAB receptors in catalepsy. The following results were obtained: 1- Muscimol (MUS), a GABAA agonist, induced catalepsy. This effect was dose-dependent. Baclofen (BAC), a GABAB agonist, had no effect in this respect. 2- Catalepsy induced by muscimol was potentiated by pretreatment of animals with bicuculline (BIC), a GABAA antagonist, while pretreatment of animals with picrotoxin (PIC), another GABAA antagonist, did not change the response. 3- The cataleptogenic effect of a-flupenthixol (a-FPT), a neuroleptic which is a potent cataleptogenic drug, was also increased by bicuculline pretreatment. Aflupenthixol, in animals pretreated with picrotoxin, induced a small but significant increase in catalepsy. 4- Muscimol catalepsy may be due to GABA inhibitory effect of the drug upon dopaminergic function, while potentiation of cataleptogenic effect of a-flupenthixol or that of muscimol by bicuculline may be exerted through release of GABA from GABAergic nerve endings
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