Volume 6, Issue 4 (2-1993)                   Med J Islam Repub Iran 1993 | Back to browse issues page

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BINDING OF THE ANTITUMOR DRUG ADRIAMYCIN TO DNA-HISTONE COMPLEXES
AZRA RABBANI , MARZIEH HAGSHARIFIA TAGAVI , BAHRAM GOLIAEI
From the Institute of Biochemistry and Biophysics, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Abstract:   (3760 Views)
Isotherms of the binding of the anthracycIine antibiotic, adriamycin (adriblastin), to DNA histone complexes was studied by means of spectroscopic analysis. The results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with DNA, (b) binding of the drug to DNA did not change the binding affinity of histone to DNA and, (c) in the explored binding range of r
Keywords: Anthracycline, Chromation, Histones, Adriomycin
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Type of Study: Original Research: Basic Science in Medicine | Subject: Biological Sciences
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