Volume 6, Issue 4 (2-1993)                   Med J Islam Repub Iran 1993 | Back to browse issues page

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ZARRINDAST M, KHAlENABI Y, POURGHOLAMI M H. BUPROPION-INDUCE D CLIMBING THROU GH D -1 AND D-2 DOPAMINE RECEPTOR ACTIVATION. Med J Islam Repub Iran. 1993; 6 (4) :285-289
URL: http://mjiri.iums.ac.ir/article-1-1474-en.html
From the Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Abstract:   (2216 Views)
Intraperitoneal (IP) injection of bupropion (3,6, amine (4,16 mg kg•') induced dose-dependent climbing in mice. The climbing response induced by both drugs were decreased in animals pretreated either with the 0-1 antagonist SCH 233<)0 or the 0-2 antagonist sulpiride. The α-adrenoceptor blocker phenoxybenzamine decreased the climbing induced by both bupropion and amphetamine, but the β-adrenergic blocker propranolol and the antimuscarinic agent atropine had no effect. Reserpine pretreatment abolished the climbing induced by bupropion but not that of amphetamine. However, alpha-methyl-ptyrosine combined with reserpine treatment reduced the amphetamine-induced climbing. It is concluded that both bupropion and amphetamine-induced climbing through release of dopamine and subsequent activation of 0-1/0-2 receptors however, the mechanisms by which dopamine is released by these drugs may differ.
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