Volume 4, Number 1 (2-1990)                   Med J Islam Repub Iran 1990 | Back to browse issues page


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NOBAKHT M, SIMFOROOSH N, MOHAMADIAN A, AMIR-ANSARI B. THE ROLE OF T-L YMPHOCYTE SUBPOPULATION IN RENAL ALLOGRAFT REJECTION. Med J Islam Repub Iran. 1990; 4 (1) :47-52
URL: http://mjiri.iums.ac.ir/article-1-1570-en.html

From the' Department of Histology, Tarbiat Modarres University
Abstract:   (1678 Views)
Twenty-two recipients of HLA-nonidentical living related and nonrelated renal allografts were studied for alterations in the relative percentage of OKT4-positive peripheral blood T-cells after transplantation. Characteristic shifts in the ratio of T-helper to T -suppressor/cytotoxic cells (TH/TS-C), but not absolute cell numbers, were demonstrated to correspond with the status of the allograft. Our results are indicative of a correlation between rejection episodes and the increase in OKT4:0KT8 ratios, that were characterized by a significant rise in the percentage of OKT4-positive cells (P=0.001), and a decrease in the percentage of OKT8-positive cells (P=0.001).
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