Abstract
Background
contributes substantially to patient morbidity and mortality.In this study we investigated
the range and distribution of T-lymphocyte. Subsets CD3
helper/inducer cell,.th ), CD8
: Severe immunosuppression occurs after large thermal burn and probably+ (T cells) CD4+ (T+ (T suppressor /Cytotoxic cells ,TS/C), CD3+CD4
thermal injury.
+/CD3+CD8+ ratio, CD19+ (B cells) and CD16+ (NK cells ) in patiens followingMethods
studied.The total body surface area of the burn injury, ranged from 30 to >70%. Whole
blood samples were collected at three and seven days postburn. Partec flowcytometry
system and triple color flowcytometry reagents (Dako Co), were used to evaluate peripheral
blood lymphocytes population of patients admitted at the Motahary Burn Center
in Tehran.
: Forty male, aging 18-60 years with major thermal injury wereResults
reduction in relative number of CD3
postburn.CD4
range in seven days following injury. CD19
burn patients at both three and seven days. The number of CD16
declined in three days and moderately increased on day seven, following injury.
Thus, the data showed that thermal burn injury suppressed T-lymphocyte subsets proliferation
in various days .In addition, all compartments of showed phenotypic changes
in the 3th and seventh days after burn, in different groups of age. Thermal burn injury
suppressed T cell subsets proliferation on day 3 and 7 postburn, when compared to normal
controls. (P <0.05) at 3 and 7 days post burn.
: Compare to healthy controls, patients with burns have shown a significant+, CD4+ and CD8+ T cells at three and seven adys+/CD8+ ratio were below normal range in three days and remained in normal+ B cell populations were elevated in+ NK cells were significantlyConclusion
factor in immunosuppression and development of sepsis in thermal burn patients.
: Significant changes in lymphocytes population could be an important| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |