Volume 9, Issue 4 (2-1996)
Med J Islam Repub Iran 1996 |
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From the Department of Internal Medicine, Silesian University School of Medicine, Tychy, Poland.
Abstract: (3766 Views)
The influence of glycosaminoglycans (GAG) on collagen fibrillogenesis in
vitro was investigated. GAG and collagen were isolated from the liver of rats treated
with carbon tetrachloride at various time intervals (3-16 weeks). It was found that
GAG obtained from the fibrotic liver accelerated collagen fibril formation. This
effect was more evident in a solution of type I collagen than type III collagen. Studies
on the liver samples showed that collagen was relatively slowly liberated in a solution
of acid from the fibrotic liver as compared to normal tissue. The observed phenomena
were related to the stage of fibrosis, i.e., to the duration of carbon tetrachloride
treatment. Therefore, a role for GAG alteration in the development of hepatic fibrosis
is suggested.
Type of Study: Original Research: Basic Science in Medicine |
Subject:
Internal Medicine
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