Volume 28, Issue 1 (1-2014)                   Med J Islam Repub Iran 2014 | Back to browse issues page

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Aminimoghaddam S, Yarandi F, Nejadsalami F, Taftachi F, Noorbakhsh F, Mahmoudzadeh F. Human chorionic gonadotrophin as an indicator of persistent ges-tational trophoblastic neoplasia. Med J Islam Repub Iran. 2014; 28 (1) :272-275
URL: http://mjiri.iums.ac.ir/article-1-2317-en.html
Tehran University of Medical Sciences, Tehran, Iran. , yarandi_f@yahoo.com
Abstract:   (1942 Views)

  Background : Gestational trophoblastic neoplasia (GTN) disease is excessive and inappropriate proliferation of trophoblast after termination of the pregnancy. Many attempts have been made to improve follow-up procedures, but no studies have evaluated Human Chorionic Gonadotrophin (HCG) as a post treatment indicator. Thus we aimed to know β-HCG variability in post treatment pregnancies.

  Methods: 40 Molar affected pregnancies were followed post-surgical treatment by serum β-HCG level in a tertiary level hospital. All subjects were treated by evacuation and followed by β-HCG every week for three weeks, then every month for six months.

  Results: 30 women were normal (group I) and 10 (group II) diagnosed as GTN cases. Serum β-HCG which obtained serially shown significant differences between two groups (p=0.001). The quantity of β-HCG/week had significantly higher level than normal females ( p<0.001)

  Conclusion: Our results suggested that β-HCG serum level could be used as a strong indicator for identifying affected patients at early stage.

 

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Type of Study: Original Research | Subject: Gynecology & Obstetrics

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