Volume 29, Issue 1 (1-2015)                   Med J Islam Repub Iran 2015 | Back to browse issues page

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Yıldırım Ş, Topaloğlu N, Tekin M, Küçük A, Erdem H, Erbaş M et al . Protective role of Proanthocyanidin in experimental ovarian torsion. Med J Islam Repub Iran 2015; 29 (1) :210-215
URL: http://mjiri.iums.ac.ir/article-1-2720-en.html
Department of Pediatrics, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey. , sule.yildirim@comu.edu.tr
Abstract:   (4571 Views)

  Background: Proanthocyanidin is a potent bioactive antioxidant naturally occurring in grape seed and acts as reactive oxygen species (ROS) scavenger. The aim of this study was to investigate the effects of proanthocyanidinin in experimental ovarian torsion injury.

  Methods : Twenty four rats were randomly divided into three groups (n=8). Group 1: the laparotomy group, group 2: ovarian torsion group, and group 3: intervention group administered proanthocyanidinin of 50 mg/kg before bilateral ovarian ischemia and reperfusion. Histologic examination and scoring was done at the end of the experiment. Statistical analyses were performed using the SPSS v. 19.

  Results : Ovarian histopathologic findings of all three groups were significantly different in terms of hemorrhage (p<0.001), edema (p=0.001) and vascular dilatation (p< 0.001). Pathologic changes induced by I/R were reduced in ovaries of rats administered proanthocyanidin, in particular, hemorrhage, edema and vascular dilatation.

  Conclusion : Proanthocyanidin, known as free radical scavenger and antioxidant, is protective against tissue damage induced by ischemia and/or ischemia/reperfusion in rat ovaries.

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Type of Study: Original Research | Subject: Pediatric

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