Volume 25, Issue 2 (7-2011)                   Med J Islam Repub Iran 2011 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mahmoudian M, Aboutaleb N, Beiranvand F, Moazzam A, Shafiei M. Noscapine antagonizes vasoconstrictor action of bradykinin in isolated human umbilical artery. Med J Islam Repub Iran. 2011; 25 (2) :82-86
URL: http://mjiri.iums.ac.ir/article-1-282-en.html
Associate Professor Department of Pharmacology, Medical School, Tehran University of MedicaSciences, Hemmat Highway, P.O.Box: 14155-6183, Tehran, Iranl , m-shafiei@tums.ac.ir
Abstract:   (4732 Views)


 Background: It has been demonstrated that noscapine, an antitussive opioid alkaloid, could antagonize bradykinin- induced responses such as bradykinin effects in guinea-pig ileum, cough induced by bradykinin receptor agonist and angiotensin converting enzyme inhibitors, and brain damage after brain edema both in neonatal rat model and in patients with stroke. In the present study, the effect of noscapine on bradykinin-induced constriction of human umbilical artery was investigated.

 Methods: Segments of human umbilical cords were obtained from women with normal full term pregnancies. Concentration-response curves for bradykinin (1-1000 nM) were constructed in the absence and presence of noscapine (1-1000 nM). To show the specificity of noscapine for bradykinin-induced constriction in the tissue, the effect of noscapine (10 pM) on vasoconstriction produced by histamine were also examined.

 Results: The results showed that noscapine could antagonize the constriction produced by bradykinin in human umbilical artery. It was also demonstrated that noscapine was capable of reducing histamine-induced contractile response.

 Conclusion: It is concluded that noscapine can antagonize bradykinin-induced constriction of human umbilical artery in a nonspecific manner. Thus, noscapine is likely to find a clinical application in pathologic conditions accompanied by higher vascular sensitivity to bradykinin in pregnancy.

Full-Text [PDF 184 kb]   (1688 Downloads)    
Type of Study: Original Research | Subject: Pharmacology

Add your comments about this article : Your username or Email:
Write the security code in the box

Send email to the article author