Volume 30, Issue 1 (1-2016)                   Med J Islam Repub Iran 2016 | Back to browse issues page

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Gouran Ourimi E, Shabani A, Alavi K, Najarzadegan M R, Mirfazeli F. A comparison of pattern of psychiatric symptoms in inpatients with bipolar disorder type one with & without methamphetamine use. Med J Islam Repub Iran 2016; 30 (1) :871-879
URL: http://mjiri.iums.ac.ir/article-1-3983-en.html
Bipolar Disorders Research Group, Iran University of Medical Sciences, Tehran, Iran. , shabani.a@iums.ac.ir
Abstract:   (4175 Views)

Background: Iran is facing an outbreak of methamphetamine-induced disorders and frequent use of these substances in patients with bipolar disorder. Using or intoxication of methamphetamine in patients with bipolar I disorder may alter the patient's clinical profile; however there is limited studies about impact of methamphetamine on clinical manifestation of bipolar disorders. This study aimed to compare psychiatric symptoms in patients with bipolar I disorder with and without concomitant use of methamphetamine.

  Methods: In a cross-sectional study, psychiatric symptoms of bipolar I disorder in patients with (Meth+) and without (Meth-) methamphetamine use was evaluated. A number of 57 participants with Meth + and 50 subjects with Meth- were recruited. The clinical picture of bipolar disorder was investigated by Young Mania Rating Scale (YMRS), 17-item Hamilton Depressive Rating Scale (HDRS-17) and the Scale for Assessment of Positive Symptoms (SAPS). Statistical comparisons were performed using the T-test for independent samples and Mann-Whitney test.

  Results: There was no statistically significant difference between two groups regarding age, duration of illness and hospitalizations. However, male participants were significantly higher in Meth+ group than in Meth- one (p<0.001). The mean (± SD) scores in the two groups of  Meth+ and Meth-  for YMRS, HDRS, and SAPS were 31.3 (±1.3) and 34.0 (±1.2), 13.7 (±0.7) and 13.5±(0.5), and 50.0 (±1.9) and  48.0 (±2.1), respectively, which were not statistically significant (p<0.05).

  Conclusion: There was no significant difference in the overall clinical manifestation of bipolar I disorder in patients with and without methamphetamine use. However, in some symptomatology domains, there were some differences between the two groups.

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Type of Study: Original Research | Subject: Psychiatry

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