Volume 19, Number 2 (8-2005)                   Med J Islam Repub Iran 2005 | Back to browse issues page


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ZANDIEH T, COHAN N, SAMIEI S, AMINI S, ATAEI Z, KAVARI M. CHARACTERISTICS AND PREVALENCE OF OCCULT HEPATITIS B VIRUS INFECTION IN PATIENTS WITH HEPATITIS C IN IRAN. Med J Islam Repub Iran. 2005; 19 (2) :147-151
URL: http://mjiri.iums.ac.ir/article-1-508-en.html

scientific Member & Assistant Professor of IBTO Iranian Blood Transfusion Organization. Sheikh Fazlollah Expressway. ShahidHemmat. Tehran, Iran. , zandyeh@ ibto.ir
Abstract:   (2797 Views)

 

ABSTRACT

 

Background: Hepatitis B virus (HBV) infection in patients who lack detectable hepatitis B surface antigen (HBsAg) is called occult hepatitis B infection. Such infections have been frequently identified in patients with chronic hepatitis Cliver disease, but their prevalence is not known.

 

Methods: 207 patients with chronic hepatitis C who were HCV -RNA and antiHCV positive were studied for HBV-DNA by PCR, and for HBsAg and anti-HBc by ELISA. DNA was extracted by high pure nucleic acid kit (Roche-Germany). HBVDNA amplification was done with a set of primer directed to the pre-S region. HBsAg and anti-HBc were evaluated by a commercially available ELISA kit (Dade Behring).

 

Results: 23 of 207 patients with chronic hepatitis Cliver disease ( 11.1%) were positive for HBV-DNA (co-infection). Among this group 17 patients (8.2%) were HBsAg negative (occult infection). 8 of 17 patients with occult infection ( 4 7%) were anti-HBc positive and 9 were anti-HBc negative (53%). No significant difference was found in epidemiological and biochemical parameters in patients with HCV alone in comparison with HCV co-infected with occult hepatitis B (p= 0.453 for ALT and p= 0.498 for AST).

 

Conclusion: Occult hepatitis B virus infections occur frequently in patients with chronic hepatitis Cliver disease and may have clinical significance.

 

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Type of Study: Original Research | Subject: Blood

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