Volume 17, Issue 3 (11-2003)                   Med J Islam Repub Iran 2003 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

PARSANEZHAD M, RAOOFI M, ALBORZI S, OMRANI G. A PROSPECTIV E, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED CLINICAL TRIAL OF DEXAMETHASONE DURING THE FOLLICULAR PHASE IN CLOMIPHENE RESISTANT PATIENTS WITH POLYCYSTIC OVARY SYNDROME AND NORMAL DHEAS. Med J Islam Repub Iran. 2003; 17 (3) :203-207
URL: http://mjiri.iums.ac.ir/article-1-682-en.html
From the Division of Infertility and Reproductive Endocrinology, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz I.R. Iran. , parsame@sums.ac.ir
Abstract:   (2695 Views)
In order to evaluate the effects of short course administration of dexamethasone (DEX) combined with clomiphene citrate (CC) in CC-resistant patients with polycystic ovary syndrome (PCaS) and normal DHEAS, a prospective, double blind, placebo controlled, randomized study was undertaken at referral university hospitals, Two-hundred and thirty women with PCOS and normal DHEAS who failed to ovulate with a routine protocol of CC received 200 mg of CC from day 5 to 9 and 2 mg of DEX from day 5 to 14 of the menstrual cycle. The control group received the same protocol of CC combined with placebo. Follicular development, hormonal status, ovulation rate, and pregnancy rate were evaluated. Mean follicular diameters were 18.4124±2.4314 mm and 13.8585±2.0722 mm (p<0.001) for treatment and placebo group respectively. Eighty-eight percent of treatment and 20% of the control group had evidence of ovulation. The difference of cumulative pregnancy rate in treatment and control groups was statistically significant (p<0.000l). Hormonal levels, follicular development and cumulative pregnancy rate improved with the addition of DEX to CC in CC-resistant patients with PCOS and normal DHEAS.This regimen is recommended before any gonadotropin therapy or surgical intervention.
Full-Text [PDF 359 kb]   (1479 Downloads)    
Type of Study: Original Research | Subject: Gynecology & Obstetrics

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author