Volume 17, Issue 3 (11-2003)                   Med J Islam Repub Iran 2003 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

ALASTI F, SANATI M. MAKING AN EXPERIMENTAL ANIMAL MODEL FOR MULTIPLE SCLEROSIS. Med J Islam Repub Iran. 2003; 17 (3) :245-249
URL: http://mjiri.iums.ac.ir/article-1-689-en.html
From the National Research Center for Genetic Engineering and Biotechnology (NRCGEB), Tehran, Iran , msanati@nrcgeb.ac.ir
Abstract:   (2080 Views)
To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptible animals, was used. Proteolipid protein (PLP) , which is a prominent neuroantigen, was extracted from fresh bovine brain, and used for inducing EAE in female Balb/c and Guinea pig. Animals were weighed and examined daily for clinical symptoms. Also histological sections from EAE brains were prepared. These sections showed infiltration, congestion and demyelination.
Full-Text [PDF 721 kb]   (549 Downloads)    

Add your comments about this article : Your username or Email:
Write the security code in the box

Send email to the article author