Volume 17, Issue 1 (5-2003)                   Med J Islam Repub Iran 2003 | Back to browse issues page

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From the Organ Transplantation Unit, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (3767 Views)
The liver transplantation program was established at Shiraz Nemazee Hospital in 1993. Shortage of cadaver organ supply due to various social and legal issues urged us to develop a living-related liver transplantation (LRLT) program. So far 7 (6 males, 1 female) living-related liver transplantations have been performed at this center. The mean age of patients was 8.21 years (+/- 4.16), with a range of 4.5 to 14 years. Live donors (3 mothers, 2 fathers, and 1 brother) with a mean age of 30.83 years (+/- 4.11) underwent procurement of the left lateral segment without mortality or any serious morbidity. The native liver disease was idiopathic cirrhosis (1 case), biliary atresia (3 cases), Budd-Chiari syndrome (1 case), neonatal cirrhosis (l case), and cryptogenic cirrhosis (l case). Allografts were implanted using piggy-back surgical technique. Baseline immunosuppression consisted of a triple drug regimen including cyclosporine, mycophenolate mofetil and steroids. Acute graft rejection was treated with intra-venous bolus of methyl-prednisolone. Early death occurred in 2 patients due to vascular thrombosis. Biliary complication was observed in 1 patient. Five patients are alive with a normal functioning liver. In conclusion, LRLT program is promising in Iran. It can help to overcome the shortage of organs and minimize the mortality of patients in the waiting list.
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Type of Study: Original Research | Subject: General