Volume 15, Number 3 (11-2001)                   Med J Islam Repub Iran 2001 | Back to browse issues page


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A. POUSTI A, BAKHTIARI S. EFF ECT OF C A RBAMAZEPINE ON THE SPONTANEOUS BEATING OF ISOLATED GUINEA PI G ATRIA. Med J Islam Repub Iran. 2001; 15 (3) :165-169
URL: http://mjiri.iums.ac.ir/article-1-800-en.html

Professor From the Department of Pharmacology, School of Medicine, Tehran Ulliversity of Medical Sciences, Tehran, l.R. Iran.
Abstract:   (1903 Views)
Carbamazepine, a drug effective in pain, seizure, and affective disorders, was studied for its effects and toxicity on spontaneously beating isolated guinea pig atria, Carbamazepine (20-􀁽0 J.lg/mL) has a negative chronotropic effect on artria, without any significant effect on contractile force. The most significant effect (12.5%) was seen with 30 J.lg/mL of carbamazepine on atria. With higher doses (>30 µg/mL) carbamazepine produced toxic effects which resulted in atrial standstill. Pretreament of atria with theophylline (5-5 0 µg/mL) prevented the negative chronotropic effect of carbamazepine (30 µg/mL). Three dose ratios of carbamazepine (1.33,2,2.33) in the presence of three different doses of theophylline (30,50 and 60 µg/mL) were obtained. These results suggest that the negative chronotropic effect of carbamazepine and its toxicity may be due to its action as an agonist on adenosine Al receptoCarbamazepine, a drug effective in pain, seizure, and affective disorders, was studied for its effects and toxicity on spontaneously beating isolated guinea pig atria, Carbamazepine (20-􀁽0 J.lg/mL) has a negative chronotropic effect on artria, without any significant effect on contractile force. The most significant effect (12.5%) was seen with 30 J.lg/mL of carbamazepine on atria. With higher doses (>30 µg/mL) carbamazepine produced toxic effects which resulted in atrial standstill. Pretreament of atria with theophylline (5-5 0 µg/mL) prevented the negative chronotropic effect of carbamazepine (30 µg/mL). Three dose ratios of carbamazepine (1.33,2,2.33) in the presence of three different doses of theophylline (30,50 and 60 µg/mL) were obtained. These results suggest that the negative chronotropic effect of carbamazepine and its toxicity may be due to its action as an agonist on adenosine Al receptors and as an antagonist on A2 receptors of the atria. Moreover, using adenosine antagonists such as theophylline may overcome the toxic effect of carbamazepine on the heart. This may explain the reason for the interaction between carbamazepine and theophylline in clinical settings.
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