Volume 14, Issue 4 (2-2001)                   Med J Islam Repub Iran 2001 | Back to browse issues page

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KERMANIZADEH P, HAGAN P, CROMPTON D. INFLUENCE OF NERVE TISSUE-DERIVED NEUROTRANSMITTERS ON MAST CELL MIGRATION. Med J Islam Repub Iran. 2001; 14 (4) :379-383
URL: http://mjiri.iums.ac.ir/article-1-843-en.html
From the Division of Immunology. Faculty of Medicine. Tabriz University of Medical Sciences. Tabriz. I. R. Iran
Abstract:   (3436 Views)
In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. Some available neurotransmitters including (substance-p, histamine, serotonin, Dopa, noradrenaline, acetylcholine, aspartic acid, epinephrine and nerve extracts) were tested. Mast cells showed a significant morphological response to 10-3 and 10-4 M histamine, 10-9 M serotonin, and 10'2 M Dopa Nerve extracts induced some shape changes in mast cells.
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