Volume 14, Issue 3 (11-2000)                   Med J Islam Repub Iran 2000 | Back to browse issues page

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NUCL EAR DNA CONTENT AND DNA PLOIDY ANALYSIS IN BREAST CANCER
F SARI ASLANI , B SALIMI
From the Department of Pathology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Abstract:   (4306 Views)
To investigate the patterns of DNA ploidy and proliferating activity in breast cancer and relate them to other prognostic factors, paraffin blocks of 53 cases of breast carcinoma were studied. Cancer cells obtained by mechanical tissue disaggregation were examined for DNA content, ploidy and S-phase fraction. DNA assay was done using a CAS interactive image analyzing system. All of the cases showed high degrees of proliferation. The rate of aneuploidy was 77% in invasive breast carcinomas. S-phase fractions were correlated with the grades of the tumors (p
Keywords: Breast cancer, S-phase fraction, Image analysis.
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Type of Study: Original Research | Subject: Pathology
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