Volume 14, Issue 1 (5-2000)                   Med J Islam Repub Iran 2000 | Back to browse issues page

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TORABI-NEZHAD S, MAFTOUN S. THE INCI DENC E OF PROS TATIC INTRAEPI THELIAL NEOPLASIA IN PROSTATIC HYPERPLASIA AND PROS TATIC C ARCINOMA. Med J Islam Repub Iran. 2000; 14 (1) :9-13
URL: http://mjiri.iums.ac.ir/article-1-892-en.html
From the Department of Pathology, Shiraz University of Medical Sciences, Shiraz, I.R.lran.
Abstract:   (2708 Views)
Prostatic intra-epithelial neoplasia (PIN) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. In this study, we applied the PIN grading system on one-hundred cases of prostatic carcinoma and one-hundred cases of benign prostatic hyperplasia, then compared the results. 74% of prostatic carcinoma and 51 % of prostatic hyperplasia cases showed PIN foci. Most of the prostatic carcinomas (61 %) showed foci of high-grade PIN including grade II (46%) and grade III (15%). In benign prostatic hyperplasia cases, only PIN grade I (26%) and grade II (25%) were seen. It is concluded that PIN and invasive adenocarcinoma of prostate are closely associated and the likelihood for coexistence is higher in patients with high grade PIN and especially if other factors such as prostate specific antigen and positive findings on sonography are also considered.
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Type of Study: Original Research | Subject: Pathology

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