Volume 13, Number 1 (5-1999)                   Med J Islam Repub Iran 1999 | Back to browse issues page


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SADEGHIPOUR ROODSARIE H, VOSOOGHl M, ZAHRAIE M. THE SYNTHESIS AND EVALUATION OF NEW DERIVATIVES OF 2,4 DIAMINOPYRIMIDINES WITH MALE CONTRACEPTIVE ACTIVITY. Med J Islam Repub Iran. 1999; 13 (1) :27-32
URL: http://mjiri.iums.ac.ir/article-1-968-en.html

Associtate Professor From the Departments of Physiology Tehran University of Medical Sciences. Tehran. I.R. lran.
Abstract:   (1585 Views)
The discovery of the antifertility activity of gossypol led scientists and researchers to the development of compounds with antifertility activity that can be used as male contraceptives. These studies resulted in discovery of the antifertility activity of several classes of compounds which have been reported in the literature. This article deals with the synthesis of four new analogues of pyrimethamine, the derivatives of 2, 4-diamino-5 (3,4-dichlorophenyl)-6-alkyloxymethyl pyrimidine (methyl ethyl, n-propyl, iso-propyl), and the results of experimental antifertility evaluation of these compounds on male rats, which revealed a significant decrease in motility, viability, ESR and DSP indices in treated animals
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Type of Study: Original Research | Subject: Physiology