Volume 12, Number 4 (2-1999)                   Med J Islam Repub Iran 1999 | Back to browse issues page


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HOSSEINZADEH H, SHOOSHTARI M. ANTINOCICEPTIVE INTERACTION BETWEEN ADENOSINE AND CARBAMAZEPINE IN MICE. Med J Islam Repub Iran. 1999; 12 (4) :381-386
URL: http://mjiri.iums.ac.ir/article-1-992-en.html

From the Department of Pharmacodynamy and Toxicology, Faculty o/Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, I.R. Iran.
Abstract:   (1705 Views)
There are several reports that adenosine and carbamazepine have pharmacodynamic interaction. I n this study the antinociceptive interaction o f these two agents was evaluated in mice by the hot plate test. Agents were injected intraperitoneally. 0.2 and 0.4 mg/kg doses of R-phenylisopropyladenosine (R-PIA) substantially showed antinociceptive effects. Carbamazepine had antinociceptive actions except at a dose of 0.8 mg/kg. Theophylline (12.5 mg/kg), as a non-selective antagonist of adenosine receptors, showed a nociceptive effect. Dipyridamole, an uptake blocker of adenosine, had no antinociceptive effect even with a dosage of 90 mg!k:g. Theophylline did not decrease the antinociceptive effect of carbamazepine, while dipyridamole increased the antinociceptive effect of carbamazepine 30 min utes after administration. Carbamazepine (8 mg/kg) inhibited the antinociceptive effect of RPIA. This study supports the possibility that the interaction between adenosine and carbamazepine may be related to their actions at adenosine receptor sites in the brain.
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