RT - Journal Article T1 - MicroRNAs as biomarkers associated with bladder cancer JF - MJIRI YR - 2016 JO - MJIRI VO - 30 IS - 1 UR - http://mjiri.iums.ac.ir/article-1-4213-en.html SP - 1282 EP - 1289 K1 - Bladder cancer K1 - Biomarkers K1 - MicroRNA K1 - Diagnostic. AB - Bladder cancer is the fifth most common cancer with significant morbidity and mortality. Recently, numerous studies demonstrated that microRNAs are emerging as diagnostic biomarkers for bladder cancer. Specific miRNA profiles have been identified for several samples from patients with bladder cancer. MicroRNAs are noncoding RNA molecules of approximately 23 nucleotides that play important roles in multiple steps during the progression of bladder cancer. Here, we review the expression profiles of miRNAs and their biological functions, regulation, and clinical implications in bladder cancer. Either downregulation or upregulation of miRNAs occurs in bladder cancer through epigenetic changes or defects of the biogenesis apparatus. Deregulation of miRNAs is involved in cell cycle arrest, apoptosis, proliferation, metastasis, drug resistance, and other functions in bladder cancer. A number of miRNAs, have been associated with tumor type, stage, or patient survival, and miRNAs might be developed as diagnostic or prognostic markers. A better understanding of the roles of miRNAs in bladder cancer will shed light on the molecular mechanisms of bladder cancer. LA eng UL http://mjiri.iums.ac.ir/article-1-4213-en.html M3 ER -