TY - JOUR JF - MJIRI JO - Med J Islam Repub Iran VL - 25 IS - 4 PY - 2011 Y1 - 2011/12/01 TI - The potential of honey to promote wound healing in periodontology: a pilot randomized clinical trial TT - N2 -  Abstract Background & Objectives: Honey has been used as a nutraceutical in many traditional and ancient remedies. Considering well documented benefits of honey to accelerate wound healing, for the first time we aimed to assess intra oral surgical wound healing process with honey. Methods: We designed a pilot randomized placebo controlled cross-over clinical trial. Patients who required bilateral Modified Widman Flap (MWF) surgery randomly assigned to receive either 15 cc topical Persian Thymus Vulgaris concentrated honey three times a day or normal saline as placebo with the same amount at the site of the surgery for seven consecutive days. After a 35-day wash-out period the study groups were crossed. The primary efficacy outcome was changes in healing index (Landry index) and the secondary efficacy outcome were changes in gingival and plaque indices (Loe & Sillness, Sillness & Loe indices). It also includes safety issues consisting of any allergic reaction, delayed healing or wound dehiscence. Results: Ten patients enrolled with the mean age of 36 (±1.5) ranged between 35-40 yrs. There was a significant improvement in wound healing considering time and treatment effects in both groups, although faster wound healing observed in honey treated patients (P SP - 177 EP - 185 AU - Khosravi Samani, Mahmood AU - Poorsattar Bejeh Mir, Arash AU - Mohammadnejad, Gholamali AU - Sajadi, Behrooz AU - Fereshtehnejad, Seyed-Mohammad AD - Babol University of Medical Sciences,Babol, Iran. KW - Dental plaque KW - Gingivitis KW - Honey KW - Periodontal surgery KW - Wound healing. UR - http://mjiri.iums.ac.ir/article-1-455-en.html ER -