AU - Izadi, Farzad AU - Hamkar, Rasool AU - Ghanbari, Hadi AU - Abdolmotallebi, Fereshteh AU - Jahandideh, Hesam TI - The role of Human papilloma virus (HPV) genotyping in recurrent respiratory papillomatosis in Rasoul Akram Hospital PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 26 VI - 2 IP - 2 4099 - http://mjiri.iums.ac.ir/article-1-503-en.html 4100 - http://mjiri.iums.ac.ir/article-1-503-en.pdf SO - MJIRI 2 AB  -  Background: The most common laryngeal mass in children is recurrent respiratory papillomatosis (RRP).  Studies have attempted to correlate viral typing and its aggressiveness. Method: 29 patients with histologically confirmed RRP enrolled in adjuvant therapies. Patients underwent several surgical interventions. Results: HPV genotyping demonstrated 45% HPV-6 and 55% HPV-11. The mean age at the first surgical intervention was 52.39 months (SD=102.28) (range from 4 months to 426 months). The mean number of surgical intervention was 10.39 (SD=7.76) (range from 2 to 30). The mean time of surgical intervals was 4.63 months (SD=4.02) (range from 2 to 24 months). In fourteen patients (48%) tracheotomy was done. All patients who had tracheotomy received alpha-interferon. One of our cases was a male who had pulmonary extension with HPV-6. Conclusion: A review of patients with RRP was regarding to HPV genotyping and need for adjuvant therapy and tracheostomy. Mean number of surgical procedure was 10/40 and nearly fourteen patients (48%) need to tracheotomy. The clinical differences between HPV6 and HPV11 disease may not be accurately predictable. Patients with less age and with HPV-11 seemed to have more severe problems, but these differences were not statistically significant which needs much more investigations for reasonable starting point of evaluation for these differences.  CP - IRAN IN - Department of Otolaryngology, ENT.HNSresearch center, Tehran University of Medical Sciences. Rasoul Akram Hospital/Niayesh St. Sattarkhan Avenue, Tehran, Iran. LG - eng PB - MJIRI PG - 90 PT - Original Research YR - 2012