AU - PARSANEZHAD, MOHAMMAD EBRAHIM AU - PAKNIAT, MAHNAZ AU - ALBORZI, SAEED AU - SCHMIDT, ERNST HEINRICH TI - A DOUBLE BLIND, RANDOMIZED, PLACEBO CONTROLLED STUDY TO ASSESS THE EFFICACY OF KETOCONAZOLE FOR REDUCING THE RISK OF OVARIAN HYPERSTIMULATION SYNDROME PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 19 VI - 2 IP - 2 4099 - http://mjiri.iums.ac.ir/article-1-509-en.html 4100 - http://mjiri.iums.ac.ir/article-1-509-en.pdf SO - MJIRI 2 AB  -  ABSTRACT Background: In order to evaluate the role ofketoconazole in the prevention of ovarian hyperstimulation syndrome (OHSS) in women with polycystic ovary syndrome (PCOS) undergoing ovarian stimulation with gonadotropins, a prospective, randomized, double-blind, placebo controlled study was done on one-hundred and nine PCOS women that had been refeiTed to be treated by gonadotropins. Methods: Alll09 women were assigned for random allocation. Group A (50 patients) received two ampoules ofhMG beginning on day 2 or 3 of the cycle and ketoconazole (50 mg/every 48 hours) starting on the first day ofhMG treatment. Group B (51 patients) received the same protocol ofhMG combined with one tablet of placebo every 48 hours. Main outcome measures were follicular development, E2levels, and pregnancy rate. Results: The total number ofhMG ampoules and duration oftreatment to attain ovarian stimulation was higher in group A (p CP - IRAN IN - P.O. Box: 71345- 1657, Shiraz-lran. LG - eng PB - MJIRI PG - 153 PT - Original Research YR - 2005