%0 Journal Article %A BOSKABADY, MH %A RAKHSHANDAH, H %A MOETAMED SHARIATI, V %T BRONCHODILATORY AND AN TICHOLINERGIC EFFECTS OF Carum copticum ON ISOLATED GUINEA PIG TRACHEAL CHAINS %J Medical Journal of the Islamic Republic Of Iran %V 11 %N 4 %U http://mjiri.iums.ac.ir/article-1-1077-en.html %R %D 1998 %K %X Carum copticum is a grassy and annual plant which is believed to have several therapeutic effects, including anti-asthmatic properties. We have therefore studied the bronchodilatory and anticholinergic effects of 4 rnL aqueous extract (AE), 0.0 5 mL ethanol extract (EE), and 0.0 0 5 mL essential oil (EO) of Carum copticum and 1 rnL of a 5 mM solution of its main ingredient, thymol (T), in comparison with 4 mL of saline (S) on isolated tracheal chains of guinea-pigs (w=500-800 g) in a 50 mL organ bath. The bronchodilatory effects of different solutions were examined by their relaxant effect on isometrically (1 g) precontracted tracheal chains by 10 µM methacholine (M). The anticholinergic effects of different solutions were tested by comparing the cumulative log concentration -response curves of tracheal chains to cumulative concentrations of M in the presence of AE, EE, EO, and T with that of S. The bronchodilatory effects of AE, EE, and EO were significantly higher than S in all cases (p %> http://mjiri.iums.ac.ir/article-1-1077-en.pdf %P 329-334 %& 329 %! Pharmacological Effects of Carum copticum %9 Original Research: Basic Science in Medicine %L A-10-1-337 %+ From the Dept. of Physiology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, I. R.lran. %G eng %@ 1016-1430 %[ 1998