AU - Ghanei, Esmat AU - Homayouni, Seyyed Mohammad AU - Nasrollahi, Alireza TI - Two cases of pseudoxanthoma elasticum with renal involvement PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 23 VI - 1 IP - 1 4099 - http://mjiri.iums.ac.ir/article-1-46-en.html 4100 - http://mjiri.iums.ac.ir/article-1-46-en.pdf SO - MJIRI 1 AB  -   Abstract   Pseudoxanthoma elasticum is a rare, hereditary, multisystemic disease affecting   the skin, eye, and cardiovascular system. Renal involvement is uncommon.   We describe two cases of pseudoxanthoma elasticum (PXE) in two women with   distinctive skin lesions and nephrocalcinosis that renal ultrasonography showed a   characteristic pattern of dotted increased echogenicity in the corticomedullary junction.   One of them had IgA nephropathy that was proven by kidney biopsy. Skin biopsy   and fundus examination confirmed the diagnosis. Early diagnosis of PXE is important   for minimizing systematic complications and informing the other family   members through genetic counseling. Our case with PXE and IgA nephropathy is the   first case report. CP - IRAN IN - Department of Internal Medicine of Shohada Hospital Shahid Beheshti University of Medical Sciences, Tehran , Iran. LG - eng PB - MJIRI PG - 53 PT - case report YR - 2009