%0 Journal Article %A BATYRALIEV, TALANTBEK A %A AYKlMBAEV, KAIRGELDY S. %A KUDEYBERDIEVA, GULMIRA Z. %A AKGUL, FERIT %A SODANBEKOVA, GYLDYZ K. %T THE EFFECTS OF CAPTOPRIL ON PULMONARY AND SYS TEMIC ARTERIAL PRESSURES IN HIGHALTITUDE PULMONARY HYPERTENSION %J Medical Journal of the Islamic Republic Of Iran %V 10 %N 3 %U http://mjiri.iums.ac.ir/article-1-1167-en.html %R %D 1996 %K Captopril, pulmonary hypertension, systemic hypertension, high-altitude pulmonary hypertension., %X The purpose of this investigation was to assess the effect of captopril on both systemic (P.a) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44±6.8 years) with HAPH and mild to moderate systemic arterial hypertension were included in the study. All patients underwent right heart catheterization with measurements of systolic PPA (PPA,syst) , mean PPA, (P¯PA) and diastolic PPA (PPA,diast)• After 4 weeks placebo phase patients with a PPA, sst> 25 mmHg, P¯PA > 15 mm Hg and systemic diastolic blood pressure (Pa,diast) >100 mmHg were given captopril (50-75 mg at 8 am) for a period of 12 weeks. The statistical evaluation of the results was made using Student's t-test. It was found that captopril significantly decreases PPA and Pa. %> http://mjiri.iums.ac.ir/article-1-1167-en.pdf %P 179-181 %& 179 %! Captopril, Arterial Pressure, and HAPH %9 Original Research %L A-10-1-423 %+ From the Department of Cardiology, Balcali Hospital, Cukurova University, Adana, Turkey. %G eng %@ 1016-1430 %[ 1996