AU - BATYRALIEV, TALANTBEK A AU - AYKlMBAEV, KAIRGELDY S. AU - KUDEYBERDIEVA, GULMIRA Z. AU - AKGUL, FERIT AU - SODANBEKOVA, GYLDYZ K. TI - THE EFFECTS OF CAPTOPRIL ON PULMONARY AND SYS TEMIC ARTERIAL PRESSURES IN HIGHALTITUDE PULMONARY HYPERTENSION PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 10 VI - 3 IP - 3 4099 - http://mjiri.iums.ac.ir/article-1-1167-en.html 4100 - http://mjiri.iums.ac.ir/article-1-1167-en.pdf SO - MJIRI 3 AB  - The purpose of this investigation was to assess the effect of captopril on both systemic (P.a) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44±6.8 years) with HAPH and mild to moderate systemic arterial hypertension were included in the study. All patients underwent right heart catheterization with measurements of systolic PPA (PPA,syst) , mean PPA, (P¯PA) and diastolic PPA (PPA,diast)• After 4 weeks placebo phase patients with a PPA, sst> 25 mmHg, P¯PA > 15 mm Hg and systemic diastolic blood pressure (Pa,diast) >100 mmHg were given captopril (50-75 mg at 8 am) for a period of 12 weeks. The statistical evaluation of the results was made using Student's t-test. It was found that captopril significantly decreases PPA and Pa. CP - IRAN IN - LG - eng PB - MJIRI PG - 179 PT - Original Research YR - 1996