RT - Journal Article T1 - THE EFFECTS OF CAPTOPRIL ON PULMONARY AND SYS TEMIC ARTERIAL PRESSURES IN HIGHALTITUDE PULMONARY HYPERTENSION JF - MJIRI YR - 1996 JO - MJIRI VO - 10 IS - 3 UR - http://mjiri.iums.ac.ir/article-1-1167-en.html SP - 179 EP - 181 K1 - Captopril K1 - pulmonary hypertension K1 - systemic hypertension K1 - high-altitude pulmonary hypertension. AB - The purpose of this investigation was to assess the effect of captopril on both systemic (P.a) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44±6.8 years) with HAPH and mild to moderate systemic arterial hypertension were included in the study. All patients underwent right heart catheterization with measurements of systolic PPA (PPA,syst) , mean PPA, (P¯PA) and diastolic PPA (PPA,diast)• After 4 weeks placebo phase patients with a PPA, sst> 25 mmHg, P¯PA > 15 mm Hg and systemic diastolic blood pressure (Pa,diast) >100 mmHg were given captopril (50-75 mg at 8 am) for a period of 12 weeks. The statistical evaluation of the results was made using Student's t-test. It was found that captopril significantly decreases PPA and Pa. LA eng UL http://mjiri.iums.ac.ir/article-1-1167-en.html M3 ER -