TY - JOUR JF - MJIRI JO - Med J Islam Repub Iran VL - 27 IS - 3 PY - 2013 Y1 - 2013/8/01 TI - Comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis TT - N2 -   Background: Delay in diagnosis and treatment of perforated appendicitis may cause life-threatening complications. The aim of this study was to determine and compare pre-operative total and direct bilirubin levels in cases of simple and perforated acute appendicitis in order to improve the clinical decision making.   Methods: This prospective observational study included eighty patients who underwent open appendectomy, during a one-year period from March 2010 to March 2011 in the surgical department of Hazrat-e-Rasool Akram Hospital, an academic teaching hospital in Tehran- Iran. Pre-operative total and direct levels of bilirubin were compared in two groups of histologically proved appendicitis (simple and perforated), each including 40 patients.   Results: Eighty patients who underwent open appendectomy including 70% men and 30% women with a mean age of 34±11 years in Group I (perforated appendicitis) and 47.5% women and 52.5% men with a mean age of 33±14 in Group II (simple appendicitis) were included in this study. The mean bilirubin levels were higher for patients with perforated acute appendicitis compared to those with a non-perforated simple appendicitis (1.04±05 mg/dl vs 0.7±0.1 mg/dl) and this difference is highly significant (p SP - 109 EP - 112 AU - Vaziri, Mohammad AU - Pazouki, Abdolreza AU - Tamannaie, Zeinab AU - Maghsoudloo, Farshid AU - Pishgahroudsari, Mohadeseh AU - Chaichian, Shahla AD - Minimally Invasive Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. KW - Appendicitis KW - Bilirubin KW - Hyperbilirubinemia KW - Perforated appendicitis. UR - http://mjiri.iums.ac.ir/article-1-1878-en.html ER -