TY - JOUR T1 - Relationship between serum levels of fetuin-A with apo-A1, apo-B100, body composition and insulin resistance in patients with type 2 diabetes TT - JF - MJIRI JO - MJIRI VL - 28 IS - 1 UR - http://mjiri.iums.ac.ir/article-1-2455-en.html Y1 - 2014 SP - 646 EP - 652 KW - Fetuin-A KW - Apo-A1 KW - Apo-B100 KW - Body Fat Percentage KW - Insulin Resistance KW - Type 2 Diabetes. N2 -   Background :Some results exist on fetuin-A as marker for vascular disease in type 2diabetes. We examined the relationship between serum fetuin-A with some factors, in patients with type 2 diabetes mellitus (T2DM).   Methods : From October 2012 to June 2013, a total of 131 T2DM patients were recruited and evaluated for various parameters including HOMA-IR, Apo-A1, Apo-B100, body fat percentage and waist circumference. Serum fetuin-A levels were measured by enzyme-linkedimmunosorbent assay (ELISA), and Serum glucose with a Cobas MIRA analyzer by enzymatic method. Apo-B100 and apo-A1 were measured by immunoturbidimetry with a Cobas MIRA analyzer. HOMA-IR was calculated by the following formula: [fasting insulin (uIU/mL) × fasting blood glucose (mmol/L)]/22.5.   Results : The mean levels of HOMA-IR were significantly increased progressively across fetuin-A tertiles (pfor trend=0.04) in women but not men. Fetuin-A had just a significant positive correlation withApo- A1(r=0.22, p=0.02).   Conclusion : This present study showed that levels of serum fetuin-A are significantly associated with insulin resistance in women with T2DM. M3 ER -