%0 Journal Article %A Sharifi, Zahra Nadia %A Movassaghi, Shabnam %A Mohamadzadeh, Farzaneh %A Soleimani Asl, Sara %A Pourheydar, Bagher %A Mehdizadeh, Mehdi %T Reduction in ischemic brain injury following the administration of pentoxifylline after transient global ischemia/ reperfusion in a rat model %J Medical Journal of the Islamic Republic Of Iran %V 29 %N 1 %U http://mjiri.iums.ac.ir/article-1-2893-en.html %R %D 2015 %K Cerebral ischemia, Reperfusion, Pentoxifylline, Hippocampus., %X   Background: It is well known that the hippocampus, the CA1 Pyramidal cells in particular, is selectively vulnerable during global cerebral ischemia. Recently, it is observed that pentoxifylline has a neuroprotective effect. This study explored the pharmacological relationship between ischemia-induced cell death of the hippocampus and the efficacy of a vasodilator agent (pentoxifylline) in the prevention of delayed neuronal death.   Methods : This experimental study was performed on 4 groups: control, ischemia, experimental (200mg/kg pentoxifylline injection one hour prior to and one hour following ischemia) and vehicle (normal saline). Transient global ischemia was induced by bilateral common carotid arteries occlusion. To investigate the apoptotic bodies and caspase-3 activities as a central role in the execution phase of apoptosis, the brains were prepared for the TUNEL technique.   Results : Pentoxifylline administration limited apoptosis and caspase-3 activities in rats’ hippocampi. Our data showed no significant difference between the number of apoptotic bodies in the CA1 region of the hippocampus in the control and pentoxifylline -treated groups (p= 0.994). The results of one- way ANOVA revealed that that ischemia significantly increased caspase-3 levels in the hippocampus (p %> http://mjiri.iums.ac.ir/article-1-2893-en.pdf %P 279-287 %& 279 %! %9 Original Research %L A-10-1-835 %+ Cellular and Molecular Research Center, Faculty of Advanced Technologies in Medicine, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran %G eng %@ 1016-1430 %[ 2015