TY - JOUR JF - MJIRI JO - Med J Islam Repub Iran VL - 24 IS - 1 PY - 2010 Y1 - 2010/5/01 TI - Combined effect of polymorphic sites in the DTNBP1 and GRIN1 genes on schizophrenia TT - N2 -     Abstract   Background: Schizophrenia is a severe mental disorder and numerous genes and loci   are beleived to be involved in this disease. Recent studies have reported a strong genetic association between DTNBP1 (dystrobrevin-binding protein 1) gene variants and schizophrenia.   Methods: In this research, we used a case-control study to establish the possible association between the P1635 (rs3213207) polymorphism in the DTNBP1 gene and schizophrenia in an Iranian cohort of 200 unrelated patients and 200 controls. The allele and genotype frequencies of the polymorphism in the two groups were determined using   PCR-RFLP and the data analyzed using logistic regression and Mantel-Haenszel chisquare tests.   Results: The additive effect of the P1635 polymorphism in DTNBP1 and the previously   reported G1001C polymorphism in the GRIN1 gene were investigated. Analysis of data   revealed a strong association between the P1635 polymorphism and schizophrenia   (AG genotype: OR=0.39, 95% CI= 0.24-0.62, P SP - 5 EP - 10 AU - Galehdari, Hamid AU - Ajam, Tahereh AU - Pooryasin, Atefeh AU - Foroughmand, Ali mohammad AU - Kazeminejad, Seyed reza AD - Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz, Iran, KW - schizophrenia; DTNBP1 gene; dysbindin; NMDA receptor; GRIN1 gene;association study UR - http://mjiri.iums.ac.ir/article-1-121-en.html ER -