@ARTICLE{Qorbani, author = {Shojaa, Mahdieh and Aghaie, Mehrdad and Qorbani, Mostafa and Khashayar, Patricia and Amoli, Mahsa and Keshtkar, Abbas Ali and Mohebi, Ramin and Ansari, Hossein and Asayesh, Hamid and Sharifi, Shima Rokn and }, title = {Association of the CTLA-4 1722TC polymorphism and systemic lupus erythematosus: a systematic review and meta analysis}, volume = {28}, number = {1}, abstract ={  Background :Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an important negative regulator of T-cell responses. The -1722TC polymorphism of the CTLA-4 gene may be associated with systemic lupus erythematosus (SLE) risk, but related results from previous studies have been inconsistent. We carried out a meta-analysis to assess this association more precisely.   Methods : A systematic search through PubMed, Science Direct, and OVID, Iran doc, Iranmedex and SID (Scientific Information Database) databases was performed with the last search updated on December 30, 2011. The odds of ratio (OR) and its 95% confidence interval (95%CI) were used to assess the strength of the association. We evaluated both fixed and random effect models, depending on the presence of between-study heterogeneity. The analyses were conducted using STATA software, version 11.0.   Results : A total of 9 independent studies on the CTLA-4 gene -1722TC polymorphism and SLE, including 1422 cases and 1417 controls were used in this meta-analysis. In the present meta-analysis, we found a significant association between -1722TC polymorphism and SLE risk in the overall analysis (TT versus TC/CC: OR=1.18, 95%CI 0.84-1.66, p= 0.32 TT/TC versus CC: OR = 2.06, 95%CI 1.07–3.99, p= 0.03 TT versus CC: OR = 2.32, 95%CI 1.62–3.32, p< 0.001 TC versus CC: OR = 1.99, 95%CI 1.42–2.78, p }, URL = {http://mjiri.iums.ac.ir/article-1-2547-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-2547-en.pdf}, journal = {Medical Journal of the Islamic Republic Of Iran}, doi = {}, year = {2014} }