%0 Journal Article %A RASOULI, MEHDI %A LEHNER, RICHARD %T ANTICALMODULIN DRUGS DUE TO THE NET EFFECTS CANNOT ANTAGONIZE DIBUTYRYL-CAMP-MEDIATED SUPPRESSION OF DE NOVO SYNTHESIZED LIPID SECRETION IN BOTH CULTURED MCARDLE CELLS AND RAT HEPATOCYTES %J Medical Journal of the Islamic Republic Of Iran %V 18 %N 1 %U http://mjiri.iums.ac.ir/article-1-652-en.html %R %D 2004 %K Calmodulin, Cyclic AMP, Hepatocyte, PhosphatidyJcholine, McArdle cells, TriacygyceroJ and VLDL., %X The effects and interaction between cAMP-analogue dibutyryl-cAMP and calmodulin antagonists were investigated on de novo synthesis and secretion of lipids in cultures of hepatoma McArdle-RH7777 cells and normal rat hepatocytes. Dibutyryl cAMP caused a significant decrease in the secretion of de novo synthesized triacyl [3H] glycerol in both cultures of McArdle cells and rat hepatocytes. The inhibitory effect of dibutyryl-cAMP was concentration-dependent and appeared at the lowest concentration examined, 5 µM. Dibutyryl-cAMP at a concentration of 50 11M suppressed secretion of triacylglycerol by approximately 38% (p %> http://mjiri.iums.ac.ir/article-1-652-en.pdf %P 45-53 %& 45 %! Inhibition of VLDL Secretion by cAMP and Calmodulin Antagonists %9 Original Research: Basic Science in Medicine %L A-10-298-111 %+ University of Sari %G eng %@ 1016-1430 %[ 2004