AU - RASOULI, MEHDI AU - LEHNER, RICHARD TI - ANTICALMODULIN DRUGS DUE TO THE NET EFFECTS CANNOT ANTAGONIZE DIBUTYRYL-CAMP-MEDIATED SUPPRESSION OF DE NOVO SYNTHESIZED LIPID SECRETION IN BOTH CULTURED MCARDLE CELLS AND RAT HEPATOCYTES PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 18 VI - 1 IP - 1 4099 - http://mjiri.iums.ac.ir/article-1-652-en.html 4100 - http://mjiri.iums.ac.ir/article-1-652-en.pdf SO - MJIRI 1 AB  - The effects and interaction between cAMP-analogue dibutyryl-cAMP and calmodulin antagonists were investigated on de novo synthesis and secretion of lipids in cultures of hepatoma McArdle-RH7777 cells and normal rat hepatocytes. Dibutyryl cAMP caused a significant decrease in the secretion of de novo synthesized triacyl [3H] glycerol in both cultures of McArdle cells and rat hepatocytes. The inhibitory effect of dibutyryl-cAMP was concentration-dependent and appeared at the lowest concentration examined, 5 µM. Dibutyryl-cAMP at a concentration of 50 11M suppressed secretion of triacylglycerol by approximately 38% (p CP - IRAN IN - LG - eng PB - MJIRI PG - 45 PT - Original Research: Basic Science in Medicine YR - 2004