TY - JOUR T1 - PARAOXONASE AND ARYLESTERASE ACTIVITY AMONG HYPERCHOLESTEROLEMIC PATIENTS TT - JF - MJIRI JO - MJIRI VL - 17 IS - 1 UR - http://mjiri.iums.ac.ir/article-1-724-en.html Y1 - 2003 SP - 67 EP - 73 KW - Paraoxonase KW - Arylesterase KW - Lipids KW - Lipoproteins KW - Arteriosclerosis KW - Polymorphism. N2 - Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We examined the activity of arylesterase and paraoxonase among healthy individuals and in patients with hypercholesterolemia. Equal activity distribution was observed among males and females for both enzymes. Arylesterase activity displayed a normal distribution in the population under study. However, paraoxonase activity demonstrated a three modal activity. Population distribution of A, B and AB polymorphism were 46, 10 and 44 percent respectively. A significant direct correlation between paraoxonase activity and triglyceride levels was observed (p M3 ER -