AU - KERMANIZADEH, P AU - HAGAN, P AU - CROMPTON, DWT TI - INFLUENCE OF NERVE TISSUE-DERIVED NEUROTRANSMITTERS ON MAST CELL MIGRATION PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 14 VI - 4 IP - 4 4099 - http://mjiri.iums.ac.ir/article-1-843-en.html 4100 - http://mjiri.iums.ac.ir/article-1-843-en.pdf SO - MJIRI 4 ABĀ  - In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. Some available neurotransmitters including (substance-p, histamine, serotonin, Dopa, noradrenaline, acetylcholine, aspartic acid, epinephrine and nerve extracts) were tested. Mast cells showed a significant morphological response to 10-3 and 10-4 M histamine, 10-9 M serotonin, and 10'2 M Dopa Nerve extracts induced some shape changes in mast cells. CP - IRAN IN - LG - eng PB - MJIRI PG - 379 PT - Original Research: Basic Science in Medicine YR - 2001