%0 Journal Article %A BEHTASH, N %A MODARES, M %A GHAEM-MAGHAMI, F %A MOUSAVI, A %A SALEHI, K %T NEOADJUVANT CHEMOTHERAPY WITH VINCRISTINE AND CISPLATIN FOLLOWED BY RADICAL HYSTERECTOMY AND PELVIC LYMPH ADENECTOMY FOR FIGO STAGE IB BULKY CERVICAL CANCER %J Medical Journal of the Islamic Republic Of Iran %V 14 %N 3 %U http://mjiri.iums.ac.ir/article-1-861-en.html %R %D 2000 %K %X Twenty patients with bulky (>4 cm size) FIGO stage IB cervical cancer were treated with cisplatin 50 mg/m2 and vincristine 1 mg/m2, administered intravenously at 10-day intervals for a total of 3 courses before radical hysterectomy. A complete clinical response was noted in 1 patient (5%) and partial response in 5 (25%). Fourteen patients (70%) had stable disease. There was no grade 3 toxicity noted. Of the 20 patients who received chemotherapy (ChT), 3 patients had parametrial and para-aortic involvement in these cases, the operation was aborted and radiation therapy given. The remaining 17 patients underwent radical hysterectomy and pelvic lymphadenectomy 10-15 days following ChT. Five of these patients (29.4%) had pelvic node metastases. Three patients had positive margins. These 8 patients received postoperative radiotherapy. Twenty-four months later 15 patients were alive (87%) and 2 had died. %> http://mjiri.iums.ac.ir/article-1-861-en.pdf %P 241-243 %& 241 %! Neoadjuvant Chemotherapy for Cervical Cancer %9 Original Research %L A-10-298-314 %+ From the Department of Gynecology-Oncology, Vali-E-Asr Hospital, Tehran University 0F Medical Sciences, Tehran, I.R. Iran. %G eng %@ 1016-1430 %[ 2000