AU - QUJEQ, DURDI TI - EFFECT OF CHRONIC LEAD POISONING ON ERYTHROCYTE PROTOPORPHYRIN IN RATS PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 14 VI - 3 IP - 3 4099 - http://mjiri.iums.ac.ir/article-1-869-en.html 4100 - http://mjiri.iums.ac.ir/article-1-869-en.pdf SO - MJIRI 3 AB  - Research has shown that exposure to lead may have adverse effects at different blood lead concentrations. Lead inhibits at least two enzymes that are essential for the formation of heme, and because of the interaction of lead with these enzymes, no iron is inserted into protoporphyrin. Therefore the concentration of protoporphyrin increases in erythrocytes. The concentration of lead was measured by atomic absorption at 217.0 nm. The erythrocyte protoporphyrin was determined following extraction into 90% ethanol. The concentration of protoporphyrin in the blood of the lead exposed rat group was increased compared to that in the control group [12.46 +/- 0.57 (mean +/- S.D., n= 72) vs. 3.89 +/- 0.42, n=68, µmollL, p CP - IRAN IN - LG - eng PB - MJIRI PG - 297 PT - Original Research YR - 2000