TY - JOUR JF - MJIRI JO - Med J Islam Repub Iran VL - 14 IS - 3 PY - 2000 Y1 - 2000/11/01 TI - EFFECT OF CHRONIC LEAD POISONING ON ERYTHROCYTE PROTOPORPHYRIN IN RATS TT - N2 - Research has shown that exposure to lead may have adverse effects at different blood lead concentrations. Lead inhibits at least two enzymes that are essential for the formation of heme, and because of the interaction of lead with these enzymes, no iron is inserted into protoporphyrin. Therefore the concentration of protoporphyrin increases in erythrocytes. The concentration of lead was measured by atomic absorption at 217.0 nm. The erythrocyte protoporphyrin was determined following extraction into 90% ethanol. The concentration of protoporphyrin in the blood of the lead exposed rat group was increased compared to that in the control group [12.46 +/- 0.57 (mean +/- S.D., n= 72) vs. 3.89 +/- 0.42, n=68, µmollL, p SP - 297 EP - 301 AU - QUJEQ, DURDI AD - From the Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, I.R. Iran KW - Erythrocyte protoporphyrin KW - lead KW - poisoning. UR - http://mjiri.iums.ac.ir/article-1-869-en.html ER -