TY - JOUR T1 - PREDICTION OF ESTROGEN RECEPTOR STATUS OF INVASIVE DUCTAL CARCINOMA OF BREAST BY HISTOLOGIC GRADE TT - JF - MJIRI JO - MJIRI VL - 14 IS - 2 UR - http://mjiri.iums.ac.ir/article-1-877-en.html Y1 - 2000 SP - 133 EP - 135 KW - Breast carcinoma KW - invasive ductal carcinoma KW - estrogen receptor KW - histologic grading. N2 - In human breast cancer, estrogen receptor (ER) status of the tumor has prognostic and therapeutic significance. However, facilities to study ER are not widely available to us. We postulated that if there is a correlation between histologic grade and ER status of invasive ductal carcinoma (IDC), it may help predict the ER status of the tumor. Of 8 4 cases of breast carcinoma referred to the Cancer I:q.stitute of Tehran for immunohisto logic study of ER in 1995, 69 cases of IDC that had adequate H & E stained slides were chosen. Using the Nottingham modifi. cation of the Bloom-Richardson grading system of IDC, all cases were scored by each of us separately. Conflicting cases were jointly reassessed until a consensus was reached. Sections of paraffin blocks were stained for ER using the avidinbiotin complex method and then they were assessed by a digital image analyzer. There was an inverse relationship between ER positivity of tumors and each of the grading parameters and theā€¢ultimate grade that were all statistically significant (p M3 ER -