AU - REZAYAT, M AU - GHAZI-KHANSARI, M AU - MOUSTAFAVI-MEHR, B AU - ZARRINDAST, MR TI - EFFECTS OF CHOLECYSTOKININ RECEPTOR ANTAGONISTS ON MORPHINE- AND COCAINEINDUCED HYPOTHERMIA PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 14 VI - 2 IP - 2 4099 - http://mjiri.iums.ac.ir/article-1-881-en.html 4100 - http://mjiri.iums.ac.ir/article-1-881-en.pdf SO - MJIRI 2 ABĀ  - The effects of cholecystokinin (CCK) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. In the present work, subcutaneous (SC) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. Administration of CCKA receptor antagonist MK-329 (0.5-1.5 mg/kg), CCKB receptor antagonist L-365, 260 (0.5-1.5 mgl kg) and CCK receptor antagonist proglumide (15-45 mg/kg) 60 min. prior to cocaine injection reduced hypothermia induced by cocaine. MK-329 or proglumide also reduced the morphine response. Single administration of MK-329 and L- 365,260 to mice decreased mice core body temperature. It is concluded that the hypothermic effect of cocaine and morphine may be mediated through CCKA and CCKB receptor mechanism(s). CP - IRAN IN - LG - eng PB - MJIRI PG - 151 PT - Original Research: Basic Science in Medicine YR - 2000