TY - JOUR JF - MJIRI JO - Med J Islam Repub Iran VL - 14 IS - 2 PY - 2000 Y1 - 2000/8/01 TI - EFFECTS OF CHOLECYSTOKININ RECEPTOR ANTAGONISTS ON MORPHINE- AND COCAINEINDUCED HYPOTHERMIA TT - N2 - The effects of cholecystokinin (CCK) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. In the present work, subcutaneous (SC) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. Administration of CCKA receptor antagonist MK-329 (0.5-1.5 mg/kg), CCKB receptor antagonist L-365, 260 (0.5-1.5 mgl kg) and CCK receptor antagonist proglumide (15-45 mg/kg) 60 min. prior to cocaine injection reduced hypothermia induced by cocaine. MK-329 or proglumide also reduced the morphine response. Single administration of MK-329 and L- 365,260 to mice decreased mice core body temperature. It is concluded that the hypothermic effect of cocaine and morphine may be mediated through CCKA and CCKB receptor mechanism(s). SP - 151 EP - 154 AU - REZAYAT, M AU - GHAZI-KHANSARI, M AU - MOUSTAFAVI-MEHR, B AU - ZARRINDAST, MR AD - From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, KW - CCK antagonists KW - cocaine KW - morphine KW - hypothermia KW - mice. UR - http://mjiri.iums.ac.ir/article-1-881-en.html ER -