TY - JOUR JF - MJIRI JO - Med J Islam Repub Iran VL - 14 IS - 2 PY - 2000 Y1 - 2000/8/01 TI - MELAS SYNDROME IN TWO IRANIAN CHILDREN TT - N2 - MELAS syndrome is a mitochondrial disorder with progressive nature, because adequate treatment is not available. Diagnosis of this mitochondrial disorder depends initially on clinical suspicion, which is strengthened by additional metabolic evidence of impaired oxidative metabolism such as high serum or C.S.F. lactate levels and confirmed by demonstration of mitochondrial abnormalities-in muscle biopsy. Here we present the clinical course and management of two children with MELAS syndrome who exhibited progressive neurologic deterioration. SP - 181 EP - 184 AU - GHOFRANI, M AU - ZAMANI, GR AD - From the Dept. of Child Neurology, Mofid Children S Hospital, Shahid Beheshti University of Medical Sciences, Tehran KW - MELAS syndrome KW - mitochondrial disorders. UR - http://mjiri.iums.ac.ir/article-1-886-en.html ER -