AU - SADEGHIPOUR ROODSARIE, H AU - VOSOOGHl, M AU - ZAHRAIE, M TI - THE SYNTHESIS AND EVALUATION OF NEW DERIVATIVES OF 2,4 DIAMINOPYRIMIDINES WITH MALE CONTRACEPTIVE ACTIVITY PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 13 VI - 1 IP - 1 4099 - http://mjiri.iums.ac.ir/article-1-968-en.html 4100 - http://mjiri.iums.ac.ir/article-1-968-en.pdf SO - MJIRI 1 ABĀ  - The discovery of the antifertility activity of gossypol led scientists and researchers to the development of compounds with antifertility activity that can be used as male contraceptives. These studies resulted in discovery of the antifertility activity of several classes of compounds which have been reported in the literature. This article deals with the synthesis of four new analogues of pyrimethamine, the derivatives of 2, 4-diamino-5 (3,4-dichlorophenyl)-6-alkyloxymethyl pyrimidine (methyl ethyl, n-propyl, iso-propyl), and the results of experimental antifertility evaluation of these compounds on male rats, which revealed a significant decrease in motility, viability, ESR and DSP indices in treated animals CP - IRAN IN - LG - eng PB - MJIRI PG - 27 PT - Original Research YR - 1999